Lizards have in general been know to actively ingest substrate materials from thier enclosures. In nature this is typically not harmfull because the materials are natural to the animals environment. there are many reasons lizards ingest substrates, which i will not discuss here, but for the sake of captive husbandry it is benificial to not include materials that can be ingested or find those that are not harmful to the animal.
I would recomend useing "bed a beast" or pure potting soil (no fertilizer addatives, this can be found in a walmart garden department) for the egg laying box, or for the substrate of your enclosure whenever a natural look is intended.
Perlite and vermiculite can cause impactions (blocking the digestive tract of the lizard), internal abrasions, and/or also contain chemicals and minerals that could damage your gecko.
Oh and i also hear that if you use bed a beast or coconut husk for your egg chamber to check it frequently because the salt content can spoil eggs. once you find eggs it is then appropriate to move them to a perlite or vermiculite container for incubation and humidity monitoring.
hope this awnseres your question, and i hope i got everything right. anyone feel free to correct me if needed.
Andrew Ellis