yeah, I was definately thinking frilled dragons too! You cover the center pole in cork bark, and have other branchs coming off of that (and attaching to the walls) for basking and climbing. THAT would be absolutely AWESOME! You would just have to make sure you put some good hiding spaces in for them, as having so much viewing area around them might make them uncomfortable.
But as for use with ball pythons. I think the only way you could make that work is if your main source of heat was a UTH, and if you had A LOT of low hides. Then the rest would just basically be wasted space I think. Or, you could put shelves in to divide it into several cages, but then you need to come up with a good idea for doors to replace the one tall door.