This all depends on the perticular animal that you are dealing with. I have around fifty beaded lizards all ages sizes and color variations. Some are aggressive and some are downright tame. Caution and care should be taken when handling any venomous lizard, how ever it is not even in the same ball park as say a Rattlesnake or any other front fanged venomous snake. While the bite from Heloderma is very painful,unless you have some kind of allergic or anafalatic reaction,it is not considered to be a lethal bite.
In any case common sense and good judgement should always be used.
HorridumAngeli

HorridumAngeli's Beaded Lizard Web site