I have never had any such adverse issues in 4 years, nor heard such feedback from anyone who followed my advice, which indicated a lack of appetite or gastric illness subsequent to Panacur treatment.

Panacur is not an antibiotic and veterinary studies have shown it to have "no significant antibacterial activity", therefore it would not adversely affect gut flora based on literature I have seen. It's method of action is not similar to most bacterostatic antibiotics, which usually inhibit DNA replication.

Fenbendazole is widely known as one of the safest antiparasitics on the market, and is used all the time for a wide variety of animals. Clinical tests on most animals reveal that the LD50 can be as high as 10-400 times the recommended label dose, and often require dosing in this amount repeatedly over the course of several days to cause significant harm. A study in cats published by the American Journal of Veterinary Research indicated that even cats dosed at 5 times the recommended dose for 3 times the duration, resulted in no ill effects. Cats, it should be noted, are often highly sensitive to medications that are considered safe for other animals, and many medicines that are perfectly safe in dogs or people, are fatal in cats.

I have seen no evidence of adverse effect on gut flora in reptiles. To the contrary, my female solare which did not want to eat, move, or burrow most of last week, began head bobbing and regained her appetite and ate approx. 200 Pogos just 2 days after treatment with Panacur. There are many people who use Panacur in reptiles. One only need browse Melissa Kaplan's anapsid.org site to find reference to it, and much of her content is based on veterinary journal sources and used directly on the Veterinary Information Network as well.



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