sounds simular with our 2 litter mates we adopted. they were fine till they reached 1 1/2 to 2 years of age. then they wanted nothing to do with each other. it became worse when jaffa came down sick and had to go to 2 different vets.
when she came home from the vets jazzy would not have anything to do with her. the very sight of jaffa would cause jazzy to go into screaming fits. we had to keep them sepereated for a time and slowly let them work it out. we confined one to a room for a while then the other. we don't let our cats roam the neighborhood. you might try confining each one of your to a different room and just let one out at a time to smell the other under a door. don't let them roam outside.
they are better but jazzy still doesn't like jaffa like they used to as babies. they are going on 4 year of age now. jazzy has taken up residence with daisy. they are the best buddies now. daisy is 11 years old and very mellow.

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