All of the captive breedings combined are a miniscule sliver of a sampling of what has gone on in nature. Even with what little we really know, we can see a lot of variation in even the most inbred lines. By looking at the comparative speed with which the wolf became the teacup chihuahua, we could probably selectively breed snakes for equally outrageous characteristics. I think size preference would be fairly simple, both in nature and in captivity. I think you could get to the point, as in the wolf example, where no matter what, you can not selectively breed chihuahuas back into a wolf.

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