Yes, it's appropriate to worry when you introduce a much smaller male. Some tips:
1) make sure the female's eating voraciously, adding considerable body bulk that indicates she's ovulating. Better, let her crawl thru your hands while you press your thumb gently into her belly. If you feel little bumps those are developing ovum. Their presence means she's more likely to be receptive to the male.
2) Weigh this: It's late in the season for your female to be experiencing her first post-brumation shed. Could you provide some dates: When she came out of brumation, when she shed, that sort of thing? And maybe some info on how she's eating?
3) I'd put them together only when i had an hour to watch them. If she's ready--and if he's ready--they'll be copulating within 10 minutes. If she simply flees, or whacks him with her tail while doing so, she's not ready: separate them and try 2-3 days later. If they DO hook up, watch them and remove them when they separate (could be 15 minutes to a couple hours). Repeat at 3-4 day intervals for optimal 3 observed copulations.
4) For those first introductions I'd keep a bucked of water handy. If she attempts to feed instead of breed, you'll be glad you can quickly submerge her and hope she lets him go quickly. You can put neosporin on any wound she might inflict. And by the way, males often (usually?) grab the female by the neck during copulation, that's normal and you shouldn't be alarmed by it. But females don't bite the males if things are going well. And there shouldn't be any constriction during the process.
Tell us more, ask us more.
td

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