I rarely handle a single thing for the first month coming into the house. I try to even avoid full cleanings of cages and stick with spot cleaning until that time has passed and depending on age and size of snake how many feedings. I would rather have a well started snake in the beginning before I deal with the tameness. On the general whole, I do rarely handle my animals and with running a rescue, I get sketchy animals in. I however feed them well and that tends to keep a lot of the bitey tendencies down.