In my opinion as many others we will never fully remove pythons from the Everglades. Given enough time(several hundred years) it would be possible for the pythons to adapt to the Everglades to where they find their niche in that ecosystem. While not in our lifetime we may end up with a distinct sub species of Burmese pythons. I doubt they would survive anywhere else in the US or they would have been there by now, but to completely rule out the chance they can find a niche is as bad as believing they could take over the US.

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